Selasa, 27 Januari 2015

** Download Ebook Human Geography: People, Place, and Culture, by Harm J. de Blij, Catherine J. Nash, Erin H. Fouberg

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Human Geography: People, Place, and Culture, by Harm J. de Blij, Catherine J. Nash, Erin H. Fouberg

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Human Geography: People, Place, and Culture, by Harm J. de Blij, Catherine J. Nash, Erin H. Fouberg

Human Geography: Culture, Society and Space challenges students to think geographically across scale and across a wide range of geographical phenomena and global issues. The authors engage the students throughout the text by posing geographical questions that encourage students to think critically about their own locality, region, nation, and world. In the Eighth Edition, the authors reformat the text to 14 chapters, provide a clear outline of key questions for each chapter, integrate their own field experiences, and rewrite the text to guide students through answers to geographic questions. The Eighth Edition includes three new chapters: "Identity: Race, Ethnicity and Gender," "Local Culture, Popular Culture, and Cultural Landscapes," and "Geographic Networks." The concepts of globalization, identity, development, sense of place, and construction of scale are infused throughout the text. The author team draws from studies in geography and across disciplines to bring a broad and up-to-date perspective on the kinds of research geographers have done and are currently doing on a wide range of human geography topics.

In the Eighth Edition, de Blij and Murphy welcome new coauthor Erin Hogan Fouberg (South Dakota State University), who brings her expertise in geography education and political geography. The author team created a new pedagogy and writing style for the Eighth Edition that make the book more accessible to students and faculty.

  • Sales Rank: #174753 in Books
  • Published on: 2006-03-03
  • Original language: English
  • Number of items: 1
  • Dimensions: 11.20" h x .79" w x 8.80" l,
  • Binding: Hardcover
  • 528 pages
Features
  • Hardcover

Review
‘…a writing style that is comforting and reassuring, coverage of human geography that is topical yet familiar, and contents and presentation that ease the reader into the topics…’ (Times Higher Education Supplement, 25 May 2007)

Most helpful customer reviews

18 of 19 people found the following review helpful.
the sole reason I got a 5 on my AP Human Geography test
By Z
This book is insightful, detailed, and interesting. I actually didn't fall asleep reading it- now if only that were true for my history textbooks! This was my textbook for an AP Human Geography class I took at my school. The teacher was barely adequate, and I basically taught myself everything from this book. H.J. de Blij knows how to write well. He doesn't just give you facts, either. You're taught how to spacially analyze worldwide phenomena, not just to memorize place names. He covers everything from political geography to urban landscapes to environmental science.

This textbook is also great if you simply want to know more about the world we live in, and wish to learn from a more international, rather than American-centric, point of view.

17 of 19 people found the following review helpful.
A Very Good Book for understanding Human Geography
By T. Shaw
As someone who holds Masters degrees in both History and Social Studies Education and actually TEACHES AP Human Geography to high school freshmen, I can safely say that DeBlij and co. have come up with a winner in the new edition. I'll admit the 7th edition was filled with misrepresentations, but the new version is such an improvement, that I have discarded the often inaccurate Rubinstein book for this one.

For those who suggest buying "Geography for Dummies" be my guest. I'll just let the title speak for itself. If you look at AP Central- the home of the College Board tests, the AP Human Geography test contains about 9-10% on the basic fundamentals of geography including physical geography. DeBlij covers more than its adequate share of the subject- outside of the instructor teaching the course.

Great for AP

8 of 9 people found the following review helpful.
One of my favorite textbooks
By Geography Fan
I used this text in my Cultural Geography course last semester. I'm not usually one to read my textbooks, but this one was really interesting, reader friendly, and filled with lots of current examples (there's even photos of Lindsay Lohan and Tony Hawk). I'm not selling this one back (and for a starving college student--that's really saying something!)

See all 13 customer reviews...

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Rabu, 07 Januari 2015

# Download Ebook Building the Real-Time Enterprise: An Executive Briefing, by Michael H. Hugos

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Building the Real-Time Enterprise: An Executive Briefing, by Michael H. Hugos

This book is organized and laid out to provide information in quickly understandable chapters and in sections within chapters. Each chapter stands on its own and provides a usable body of information on an aspect of the real-time enterprise. Chapters includes diagrams, tables, and lists to illustrate and summarize key points and real-world case studies and executive interviews to provide further insight into the subject matter presented in the chapter.

Readers of this book will:

  • Gain a clear picture of how organizations can profit from use of real-time operations
  • Appreciate the theory, technology, and business practices that underpin the real-time enterprise
  • Learn a pragmatic and efficient approach for developing real-time systems in their own organizations

The author, Michael Hugos, is the chief information officer of Network Services Company, a $7 billion dollar distribution organization. He has over 20 years experience in applying technology to meet business challenges and he holds an MBA from Northwestern University’s Kellogg School of Management. His discussion of the real-time enterprise is a blend of both theoretical and practical perspectives based on his years of applying real-time concepts to actual business situations. He is also the author of Essentials of Supply Chain Management.

  • Sales Rank: #3523165 in Books
  • Published on: 2004-11-23
  • Original language: English
  • Number of items: 1
  • Dimensions: 9.15" h x .81" w x 6.24" l, 1.05 pounds
  • Binding: Hardcover
  • 224 pages

From the Back Cover
BUILDING THE REAL-TIME ENTERPRISE.

"Finally, the vision of the real-time enterprise defined in terms management and business people can understand. Hugos has cleared a path for companies wanting to deliver more value faster to the customer base and gain real competitive advantage. How? By working in a real-time enterprise, you can see all of the pieces of business in motion simultaneously, understand their relation to each other, and simply make better business decisions. It is the promise of IT delivered...tools that turn information into knowledge...knowledge into action...and action into results." - Dale F. Reeves, Director of Global eBusiness, JohnsonDiversey Inc.

"This book is a must-read for COOs, CFOs, and CIOs. Mr. Hugos lays out a road map that includes best practice tools and techniques to define, understand, devise, and implement real-time initiatives. The elegantly simple approach to systems development allows for economies in development and shows how best to maneuver through change. Of special interest were the Executive Insight sections at the end of each chapter, and the real-world cases proved invaluable." - Robert G. Grazulis, Vice president of Project Management Office, Options Clearing Corporation

The real-time enterprise is not another IT fad...it is here to stay. Companies that leverage the power of real-time information will far surpass their competition. Building the Real-Time Enterprise provides a concise overview of how a real-time enterprise works, what competitive advantage it offers, and pragmatic strategies to implement it in your organization.

Learn how to maximize internal operating efficiencies, spot new opportunities, and respond to them instantly with the help of Building the Real-Time Enterprise.

About the Author
Michael Hugos is CIO with Network Services Company, a $7-billion distribution co-op that is wholly owned by eighty-five member companies. Hugos has more than twenty years of experience in all aspects of information technology. In 2003, CIO Magazine presented Mr. Hugos and his company with the CIO 100 Award, which is given to the top 100 companies that successfully integrate operational systems and processes across their organizations. Hugos is the author of Essentials of Supply Chain Management, is a frequent speaker, and has written numerous articles for CIO Magazine, ComputerWorld, and Darwin Magazine.

Most helpful customer reviews

4 of 4 people found the following review helpful.
A safe journey to the Real-time Enterprise
By Fc Lochner
Building the Real-Time Enterprise: An Executive Briefing by Michael Hugos is a timely compendium of lessons about tested and proofed management and operational techniques for all CIO's wanting to create successful internal IT organizations in the global village we live and work in. How is an IT organization to spend its scarce resources to enable its business to excel in a world characterized by hyper-competition and co-opetition? Hugos defines the Real-time Enterprise and systematically explains its business foundations, supported by practical examples. Short overview sections on Information Theory, Cybernetics, General Systems Theory, Total Quality Management, Six Sigma, Business Process Management, System Dynamics and Viable Systems Model, to name a few, provide contextual settings in which the roots for the modern Real-time Enterprise are to be found. The book continues by explaining how to design a real-time enterprise. It does so by motivating the need for change and dynamic management, right through descriptions of real-time observation and action chains [the Observe-Orient-Decide-Act loop, borrowed from aerial warfare]and to guidance on where to start the journey toward the Real-time Enterprise once resolved as strategy. Directions of how to build an IT infrastructure for Real-time Enterprises, and tested project management methodologies are combined to serve as a Best Practice manual towards sure results. Decision-making, modern programming languages, social skills and people management, and the various steps of the system development life cycle, are all described in the context of creating the Real-time Enterprise. Of particular value is sections on hard lessons learned in successes and failures as the author experienced them in his career, and how these are of value in systematically moving towards the Real-time Enterprise. These lessons are classified in strategic guidelines for system design and tactical principles for running projects. Every chapter in the book is supported by a vignette describing a particular executive insight related to the chapter content, and this is where the book's ultimate value lies; it is based on the professional experience of an author, also award-winning CIO, having changed the organization he works for to a Real-time Enterprise with sustainable growth and success in the world of today. Having read Building the Real-time Enterprise left me with fresh and profound insights on how to optimize executive effort and organizational resources for the creation of a dynamic and agile IT capacity in the modern organization. Free of clichés, this book has set a benchmark to be followed as an example of how to combine theoretical principles with practical lessons and verified successes in the IT world. It won't easily be replaced as company on my professional journey!

2 of 3 people found the following review helpful.
Outstanding practicle advice
By Ergin Uskup
Based on over 35 years of experience leading Information Technology organziations as a CIO, I believe that the book by Hugos is a must read for both CIO's and other business function leaders. The book reflects Hugos' vast experience as a CIO and contains practical advice for both. For CIO's, Hugos not only provides realistic and common-sense advice on "what and how" to do things, but perhaps more importantly, "what and how" NOT to do things. CIO's can earn their keeps often by not falling into the trap of following the hype--many companies implement complex and expensive systems like ERP's and CRM's without compelling business case--just to "join the club." Hugos correctly points out that often adding futures and functions to existing well-run systems is a better (safer, faster, cheaper) way to address business needs.

His practical advice to functinal business leaders also hit the target. Particularly valuable are his suggestions on how to ensure IT projects should be structured to succeed and once they are started, how to make sure they are implemented on time and on budget.

3 of 3 people found the following review helpful.
Building a Real-Time Enterprise: An Executive Briefing
By Michael J. Chakos
Useful book for the busy executive: I am the CFO of my organization and manage many operating units. I have read Mr. Hugos' book and found it refreshing, to the point and extremely useful. In particular the last chapter has armed me with all of the important questions that provide the framework for keeping all projects on task and within budget. These questions provide a common communication framework between technical people and business unit managers that result in projects that stay focused and on track.

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Senin, 05 Januari 2015

!! PDF Ebook Have Fun with American Heroes: Activities, Projects and Fascinating Facts, by David C. King

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Have Fun with American Heroes: Activities, Projects and Fascinating Facts, by David C. King

Who is your favorite American hero—Thomas Jefferson, Susan B. Anthony, Martin Luther King, Cesar Chavez, or Sally Ride? Many of these men and women took risks to secure freedom for all Americans—including you and your family. Have Fun with American Heroes is filled with brief biographies, fascinating facts, and interesting quotes from our most well-known and popular American heroes. The book also contains fun-filled experiments and activities that will stretch your imagination and give you a better appreciation of these historical figures.

  • Sales Rank: #2160411 in Books
  • Published on: 2005-12-19
  • Original language: English
  • Number of items: 1
  • Dimensions: 11.00" h x .38" w x 8.55" l, .75 pounds
  • Binding: Paperback
  • 128 pages

From the Back Cover
Fascinating Facts and Fun Projects

Who is your favorite American hero—Thomas Jefferson, Susan B. Anthony, Martin Luther King Jr., Cesar Chavez, or Sally Ride? Many of these men and women took risks to secure freedom for all Americans—including you and your family.

Have Fun with American Heroes is filled with brief biographies, fascinatingfacts, and interesting quotes from our most well-known and popular American heroes.The book also contains fun-filled experiments and activities that will stretch yourimagination and give you a better appreciation of these historical figures.

While you are learning about the dramatic lives ofAmerican heroes you will also discover how to

  • Celebrate our nation's first flag-maker Betsy Ross by making a deliciousice cream flag cake.
  • Imitate inventor Thomas Edison and make a flashlight that really works.
  • Write up a story from your life and add it to a homemade autobiographylike the one Frederick Douglass wrote about his life as a slave.
  • Compare baseball giant Babe Ruth's statistical record to that of one oftoday's many baseball greats.
  • Build a model moonscape and pretend you are taking "One giant leap for mankind" with astronaut Neil Armstrong.

Get to know dozens of true American heroes and have fun while you are learning.

About the Author
David C. King is a former history teacher and an award-winning author who has written more than thirty books for children and young adults, including the books in Wiley's American Kids in History and American Heritage, American Voices series.

Most helpful customer reviews

0 of 0 people found the following review helpful.
Fantastic Product!
By Amazon Customer
This book is exactly what I've been looking for! I had all the dry facts already, but wanted to liven up our curriculum with projects and activities. Have Fun with American Heroes will do just that! I can't wait to use it with our homeschool program.

0 of 0 people found the following review helpful.
Great simple projects and good information for a k-4th grader
By mateojm
I'm using this for our U.S. History class at our homeschool co op. Great simple projects and good information for a k-4th grader.

0 of 0 people found the following review helpful.
good book
By Martha Hurley
I like the book and I got it at the scheduled time.
Yes I recommend this book for 8 and up year old kids.

See all 4 customer reviews...

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# Ebook Download Advanced Engineering Thermodynamics, by Adrian Bejan

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Advanced Engineering Thermodynamics, by Adrian Bejan

A brand-new, thought-provoking edition of the unmatched resource on engineering thermodynamics

Adrian Bejan's Advanced Engineering Thermodynamics established itself as the definitive volume on this challenging subject. Now, his Third Edition builds on the success of its trailblazing predecessors by providing state-of-the-art coverage in a slimmer, more convenient book.

Moving effortlessly among analysis, essay, and graphics, this streamlined edition of Adrian Bejan's powerful presentation will inspire future generations of researchers and students in all areas of engineering, physics, and life sciences. It features:
* An authoritative treatment of the first and second laws of thermodynamics and the constructal law of natural generation of flow configuration, with prominent focus on the history of the discipline and its main ideas
* Complete chapters on single-phase systems, multiphase systems, chemically reactive systems, exergy analysis, thermodynamic optimization, irreversible thermodynamics, and constructal theory
* Applications of thermodynamics to power generation, solar energy, refrigeration, air conditioning, thermofluid design, and constructal design
* The latest theoretical advances made based on the constructal law: atmospheric circulation and earth climate, animal design (flying, running, swimming), hierarchy and geography of human settlements, scaling laws of all river basins, flow fossils and Egyptian pyramids, and science as a constructal flow architecture
* A wealth of problems and worked-out examples
* Brilliant, original illustrations, plus hundreds of classic and contemporary references

  • Sales Rank: #78461 in Books
  • Published on: 2006-08-18
  • Original language: English
  • Number of items: 1
  • Dimensions: 9.50" h x 2.00" w x 6.40" l, 3.02 pounds
  • Binding: Hardcover
  • 920 pages

Review
"Reading the book is a delightful experience that encourages the reader to further deepen his understanding of thermodynamics and the thermal sciences." (Science Direct, December 9, 2007)

"Reading this book is a delightful experience that encourages the reader to further deepen his understanding of thermoydnamics..."
—Jaime Cervantes-de Gortari (Internation Journal of Heat & Mass Transfer, Dec. 2006)

From the Inside Flap
Since its publication almost a decade ago, Adrian Bejan’s Advanced Engineering Thermodynamics has established itself as the definitive modern treatment of this challenging subject. Now the Second Edition brings this important work fully up to date with current analyses and practices, and explores uncharted territory along the promising frontier of contemporary research. Grounded in the axiomatic formulation and Gibbsian analytical structure of classical thermodynamics, this revised volume offers an incisive examination of the history, concepts, and language of thermodynamics. Readers will find a clear review of the first and second laws of thermodynamics, along with enhanced material on exergy analysis methods, entropy generation minimization, and related design applications. The Second Edition takes an in-depth look at the latest developments in the field in areas such as power generation, solar energy, low-temperature refrigeration, air conditioning, and thermal design. Bridging the gap between physics and biology, this book, for the first time, provides a fascinating introduction to the constructal theory of macroscopic organization in nature, extending thermodynamics into the realm of naturally organized systems. Geometric shape and structure are deduced from a single principle of thermodynamic optimization. Complete with original problems, worked-out examples, exceptional graphics, and hundreds of references throughout, Advanced Engineering Thermodynamics, Second Edition is the ideal cutting-edge reference for today’s professional engineers and researchers as well as a superb resource for advanced engineering students.

From the Back Cover
A brand-new, thought-provoking edition of the unmatched resource on engineering thermodynamics

Adrian Bejan's Advanced Engineering Thermodynamics established itself as the definitive volume on this challenging subject. Now, his Third Edition builds on the success of its trailblazing predecessors by providing state-of-the-art coverage in a slimmer, more convenient book.

Moving effortlessly among analysis, essay, and graphics, this streamlined edition of Adrian Bejan's powerful presentation will inspire future generations of researchers and students in all areas of engineering, physics, and life sciences. It features:

  • An authoritative treatment of the first and second laws of thermodynamics and the constructal law of natural generation of flow configuration, with prominent focus on the history of the discipline and its main ideas
  • Complete chapters on single-phase systems, multiphase systems, chemically reactive systems, exergy analysis, thermodynamic optimization, irreversible thermodynamics, and constructal theory
  • Applications of thermodynamics to power generation, solar energy, refrigeration, air conditioning, thermofluid design, and constructal design
  • The latest theoretical advances made based on the constructal law: atmospheric circulation and earth climate, animal design (flying, running, swimming), hierarchy and geography of human settlements, scaling laws of all river basins, flow fossils and Egyptian pyramids, and science as a constructal flow architecture
  • A wealth of problems and worked-out examples
  • Brilliant, original illustrations, plus hundreds of classic and contemporary references

Most helpful customer reviews

0 of 0 people found the following review helpful.
Written well enough on a very complicated subject. But ...
By Jpem1415
Written well enough on a very complicated subject. But I do wish that were more over-arching connections between the sections of each chapter.

7 of 8 people found the following review helpful.
Too Wordy
By Aero
In our graduate level course, we were forced to use this terrible book. The committee, for some reason, approved this book even if the professors dislike it. The book problems are very wordy and the book does not contain all the information to complete the problem. After much outcry of my classmates, our professor decided to drop the book. We now use our professor's notes and problems.

Please choose another graduate level textbook.

8 of 10 people found the following review helpful.
A must-read in the field
By A. Isabel Costa
This book is truly engaging and many chapters are simply memorable.

Unlike many similarly hefty texts, this new edition of Advanced Engineering Thermodynamics gives a lucid, informative and insightful approach to the laws of thermodynamics and their real-world applications. Moreover, it also reports on the latest advances made based on the author's constructal theory. The text flows smoothly, with excellent illustrations and has been meticulously proofread, a credit to both Dr. Bejan and his editors.

I thoroughly enjoyed reading this 3rd edition of Advanced Engineering Thermodynamics; therefore, I can most sincerely recommend it. In summary: a must-read in the field for university students and scientific researchers alike.

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Jumat, 26 Desember 2014

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  • Sales Rank: #16529066 in Books
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New Frontiers in Asymmetric CatalysisFrom Wiley-Interscience

A compilation of recent advances and applications in asymmetric catalysis

The field of asymmetric catalysis has grown rapidly and plays a key role in drug discovery and pharmaceuticals. New Frontiers in Asymmetric Catalysis gives readers a fundamental understanding of the concepts and applications of asymmetric catalysis reactions and discusses the latest developments and findings. With contributions from preeminent scientists in their respective fields, it covers:

* "Rational" ligand design, which is critically dependent on the reaction type (reduction, oxidation, and C-C bond formation)
* Recent findings on activation of C-H bonds, C-C bonds, and small molecules (C=O, HCN, RN=C, and CO2) and the latest developments on C-C bond reorganization, such as metathesis
* Advances in "chirally economical" non-linear phenomena, racemic catalysis, and autocatalysis
* Some of the recent discoveries that have led to a renaissance in the field of organocatalysis, including the development of chiral Brönstead acids and Lewis acidic metals bearing the conjugate base of the Brönstead acids as the ligands and the chiral bi-functional acid/base catalysts

The book ends with a thought-provoking perspective on the future of asymmetric catalysis that addresses both the challenges and the unlimited potential in this burgeoning field. This is an authoritative, up-to-date reference for organic chemists in academia, government, and industries, including pharmaceuticals, biotech, fine chemicals, polymers, and agriculture. It is also an excellent textbook for graduate students studying advanced organic chemistry or chemical synthesis.

  • Sales Rank: #6112696 in Books
  • Published on: 2007-05-04
  • Original language: English
  • Number of items: 1
  • Dimensions: 9.55" h x 1.08" w x 6.48" l, 1.69 pounds
  • Binding: Hardcover
  • 418 pages

Review
"[The] editors have succeeded admirably in inviting interesting authors to assemble a handy overview of the most important reactions and a number of concepts ... .The present monograph has achieved the goal of covering truly interesting reactions and catalysts." (Organic Chemistry Portal, May 2009)

"...this book has definite value and is strongly recommended for inclusion in both academic and industrial research libraries."  (Angewandte Chemie, Intern. Edition, November 2007)

From the Back Cover
A compilation of recent advances and applications in asymmetric catalysis

The field of asymmetric catalysis has grown rapidly and plays a key role in drug discovery and pharmaceuticals. New Frontiers in Asymmetric Catalysis gives readers a fundamental understanding of the concepts and applications of asymmetric catalysis reactions and discusses the latest developments and findings. With contributions from preeminent scientists in their respective fields, it covers:

  • "Rational" ligand design, which is critically dependent on the reaction type (reduction, oxidation, and C-C bond formation)

  • Recent findings on activation of C-H bonds, C-C bonds, and small molecules (C=O, HCN, RN=C, and CO2) and the latest developments on C-C bond reorganization, such as metathesis

  • Advances in "chirally economical" non-linear phenomena, racemic catalysis, and autocatalysis

  • Some of the recent discoveries that have led to a renaissance in the field of organocatalysis, including the development of chiral Brönstead acids and Lewis acidic metals bearing the conjugate base of the Brönstead acids as the ligands and the chiral bi-functional acid/base catalysts

The book ends with a thought-provoking perspective on the future of asymmetric catalysis that addresses both the challenges and the unlimited potential in this burgeoning field. This is an authoritative, up-to-date reference for organic chemists in academia, government, and industries, including pharmaceuticals, biotech, fine chemicals, polymers, and agriculture. It is also an excellent textbook for graduate students studying advanced organic chemistry or chemical synthesis.

About the Author
Koichi Mikami is Professor in the Department of Applied Chemistry at the Tokyo Institute of Technology.

Mark Lautens is AstraZeneca Professor of Organic Synthesis and Merck Frosst/NSERC Industrial Research Chair in the Davenport Laboratories at the University of Toronto.

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Minggu, 14 Desember 2014

# Download PDF Pharmacometrics: The Science of Quantitative PharmacologyFrom Wiley-Interscience

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Pharmacometrics is the science of interpreting and describing pharmacology in a quantitative fashion. The pharmaceutical industry is integrating pharmacometrics into its drug development program, but there is a lack of and need for experienced pharmacometricians since fewer and fewer academic programs exist to train them. Pharmacometrics: The Science of Quantitative Pharmacology lays out the science of pharmacometrics and its application to drug development, evaluation, and patient pharmacotherapy, providing a comprehensive set of tools for the training and development of pharmacometricians.

Edited and written by key leaders in the field, this flagship text on pharmacometrics:

  • Integrates theory and practice to let the reader apply principles and concepts.
  • Provides a comprehensive set of tools for training and developing expertise in the pharmacometric field.
  • Is unique in including computer code information with the examples.

This volume is an invaluable resource for all pharmacometricians, statisticians, teachers, graduate and undergraduate students in academia, industry, and regulatory agencies.

  • Sales Rank: #1231704 in Books
  • Published on: 2007-04-06
  • Original language: English
  • Number of items: 1
  • Dimensions: 10.45" h x 2.75" w x 7.35" l, 4.85 pounds
  • Binding: Hardcover
  • 1216 pages

Review
"…this landmark text is the first to pull together and present in one volume the many facets of pharmacometrics." (American Journal of Pharmaceutical Education, Vol 71, No. 4, 2007)

From the Back Cover
Learn how to perform pharmacometrics to improve drug development success rates

This landmark text is the first to pull together and present in one volume the many facets of pharmacometrics. It features an international team of editors and authors who are experts in the field. Readers gain the knowledge base needed to perform pharmacometric analyses, interpret the results, and communicate these results to key decision makers. In particular, the text emphasizes the role of pharmacometrics in drug development, reflecting the field's enormous potential to increase drug development productivity.

Following an introduction that sets forth key landmarks in the history of pharmacometrics, a section on general principles features such topics as essential programming methods and techniques for pharmacometric analysis software validation. Next, the text presents a series of sections designed to enable readers to gain the knowledge needed to grasp pharmacometrics and then apply that knowledge to practical applications:

  • Population pharmacokinetic basis of pharmacometrics
  • Pharmacokinetics/pharmacodynamics relationship, including pharmacogenomics
  • Clinical trial designs
  • Pharmacometric knowledge creation including clinical trial simulation
  • Pharmacometric service and communication
  • Specific application examples

In addition to its clear and straightforward presentation of theory and methodology, the text features application examples with codes in NONMEM®, S-PLUS®, WinNonlin®, WinNonmix®, ADAPT®, and MATLAB®. Readers can reproduce the examples themselves and gain a deeper understanding of the many practical benefits of pharmacometrics.

Clinical pharmacologists/pharmacokineticists and pharmacometricians in drug development and pharmacotherapy, as well as students in clinical pharmacy, pharmaceutical sciences, and clinical pharmacology, should take advantage of this text to gain the training and knowledge needed to excel in pharmacometrics. More experienced pharmacometricians will want to keep the text on hand to address questions and further develop their skills.

About the Author
ENE I. ETTE, PhD, is a Fellow of the American Colleges of Clinical Pharmacy and Clinical Pharmacology. He is the President/CEO of Anoixis Corp. and was formerly the senior director and head of clinical pharmacology at Vertex Pharmaceuticals, Inc. He is also an adjunct professor of applied pharmaceutical sciences at the University of Rhode Island. Dr. Ette was a pioneer pharmacometric staff in the Office of Clinical Pharmacology and Biopharmaceutics at the Food and Drug Administration, where he developed the popular reference Guidance for Industry: Population Pharmacokinetics. From 1989 –2001, he was an FDA Consultant. In recognition of his contributions to clinical pharmacy and clinical pharmacology, Dr. Ette is the recipient of The American College of Clinical Pharmacy's Russell Miller Award. He is also the 2006 recipient of The American College of Clinical Pharmacy's Therapeutic Frontiers Lecture Award. Dr. Ette is chairman of the pharmacometrics panel of The Annals of Pharmacotherapy editorial board.

PAUL J. WILLIAMS, PharmD, is a Fellow of the American Colleges of Clinical Pharmacy and Clinical Pharmacology and Professor of Pharmaceutical Sciences and Pharmacy Practice at the Thomas J. Long School of Pharmacy and Health Sciences. Dr. Williams is the Vice President, Strategic Consulting, West Coast Operations in Anoixis Corp. and was formerly a partner at Trials by Design, LLC, a clinical consulting company, and member of the editorial board for The Annals of Pharmacotherapy. Dr. Williams is the 2006 winner of the University of the Pacific Faculty Research Award, the Long's Faculty Fellowship, and Teacher of the Year.

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