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• Sales Rank: #16529066 in Books
• Original language: English
• Binding: Hardcover

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A compilation of recent advances and applications in asymmetric catalysis

The field of asymmetric catalysis has grown rapidly and plays a key role in drug discovery and pharmaceuticals. New Frontiers in Asymmetric Catalysis gives readers a fundamental understanding of the concepts and applications of asymmetric catalysis reactions and discusses the latest developments and findings. With contributions from preeminent scientists in their respective fields, it covers:

* "Rational" ligand design, which is critically dependent on the reaction type (reduction, oxidation, and C-C bond formation)
* Recent findings on activation of C-H bonds, C-C bonds, and small molecules (C=O, HCN, RN=C, and CO2) and the latest developments on C-C bond reorganization, such as metathesis
* Advances in "chirally economical" non-linear phenomena, racemic catalysis, and autocatalysis
* Some of the recent discoveries that have led to a renaissance in the field of organocatalysis, including the development of chiral Brönstead acids and Lewis acidic metals bearing the conjugate base of the Brönstead acids as the ligands and the chiral bi-functional acid/base catalysts

The book ends with a thought-provoking perspective on the future of asymmetric catalysis that addresses both the challenges and the unlimited potential in this burgeoning field. This is an authoritative, up-to-date reference for organic chemists in academia, government, and industries, including pharmaceuticals, biotech, fine chemicals, polymers, and agriculture. It is also an excellent textbook for graduate students studying advanced organic chemistry or chemical synthesis.

• Sales Rank: #6112696 in Books
• Published on: 2007-05-04
• Original language: English
• Number of items: 1
• Dimensions: 9.55" h x 1.08" w x 6.48" l, 1.69 pounds
• Binding: Hardcover
• 418 pages

Review
"[The] editors have succeeded admirably in inviting interesting authors to assemble a handy overview of the most important reactions and a number of concepts ... .The present monograph has achieved the goal of covering truly interesting reactions and catalysts." (Organic Chemistry Portal, May 2009)

"...this book has definite value and is strongly recommended for inclusion in both academic and industrial research libraries."  (Angewandte Chemie, Intern. Edition, November 2007)

From the Back Cover
A compilation of recent advances and applications in asymmetric catalysis

The field of asymmetric catalysis has grown rapidly and plays a key role in drug discovery and pharmaceuticals. New Frontiers in Asymmetric Catalysis gives readers a fundamental understanding of the concepts and applications of asymmetric catalysis reactions and discusses the latest developments and findings. With contributions from preeminent scientists in their respective fields, it covers:

• "Rational" ligand design, which is critically dependent on the reaction type (reduction, oxidation, and C-C bond formation)

• Recent findings on activation of C-H bonds, C-C bonds, and small molecules (C=O, HCN, RN=C, and CO2) and the latest developments on C-C bond reorganization, such as metathesis

• Advances in "chirally economical" non-linear phenomena, racemic catalysis, and autocatalysis

• Some of the recent discoveries that have led to a renaissance in the field of organocatalysis, including the development of chiral Brönstead acids and Lewis acidic metals bearing the conjugate base of the Brönstead acids as the ligands and the chiral bi-functional acid/base catalysts

The book ends with a thought-provoking perspective on the future of asymmetric catalysis that addresses both the challenges and the unlimited potential in this burgeoning field. This is an authoritative, up-to-date reference for organic chemists in academia, government, and industries, including pharmaceuticals, biotech, fine chemicals, polymers, and agriculture. It is also an excellent textbook for graduate students studying advanced organic chemistry or chemical synthesis.

About the Author
Koichi Mikami is Professor in the Department of Applied Chemistry at the Tokyo Institute of Technology.

Mark Lautens is AstraZeneca Professor of Organic Synthesis and Merck Frosst/NSERC Industrial Research Chair in the Davenport Laboratories at the University of Toronto.

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# Download PDF Pharmacometrics: The Science of Quantitative PharmacologyFrom Wiley-Interscience

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Pharmacometrics is the science of interpreting and describing pharmacology in a quantitative fashion. The pharmaceutical industry is integrating pharmacometrics into its drug development program, but there is a lack of and need for experienced pharmacometricians since fewer and fewer academic programs exist to train them. Pharmacometrics: The Science of Quantitative Pharmacology lays out the science of pharmacometrics and its application to drug development, evaluation, and patient pharmacotherapy, providing a comprehensive set of tools for the training and development of pharmacometricians.

Edited and written by key leaders in the field, this flagship text on pharmacometrics:

• Integrates theory and practice to let the reader apply principles and concepts.
• Provides a comprehensive set of tools for training and developing expertise in the pharmacometric field.
• Is unique in including computer code information with the examples.

This volume is an invaluable resource for all pharmacometricians, statisticians, teachers, graduate and undergraduate students in academia, industry, and regulatory agencies.

• Sales Rank: #1231704 in Books
• Published on: 2007-04-06
• Original language: English
• Number of items: 1
• Dimensions: 10.45" h x 2.75" w x 7.35" l, 4.85 pounds
• Binding: Hardcover
• 1216 pages

Review
"…this landmark text is the first to pull together and present in one volume the many facets of pharmacometrics." (American Journal of Pharmaceutical Education, Vol 71, No. 4, 2007)

From the Back Cover
Learn how to perform pharmacometrics to improve drug development success rates

This landmark text is the first to pull together and present in one volume the many facets of pharmacometrics. It features an international team of editors and authors who are experts in the field. Readers gain the knowledge base needed to perform pharmacometric analyses, interpret the results, and communicate these results to key decision makers. In particular, the text emphasizes the role of pharmacometrics in drug development, reflecting the field's enormous potential to increase drug development productivity.

Following an introduction that sets forth key landmarks in the history of pharmacometrics, a section on general principles features such topics as essential programming methods and techniques for pharmacometric analysis software validation. Next, the text presents a series of sections designed to enable readers to gain the knowledge needed to grasp pharmacometrics and then apply that knowledge to practical applications:

• Population pharmacokinetic basis of pharmacometrics
• Pharmacokinetics/pharmacodynamics relationship, including pharmacogenomics
• Clinical trial designs
• Pharmacometric knowledge creation including clinical trial simulation
• Pharmacometric service and communication
• Specific application examples

In addition to its clear and straightforward presentation of theory and methodology, the text features application examples with codes in NONMEM®, S-PLUS®, WinNonlin®, WinNonmix®, ADAPT®, and MATLAB®. Readers can reproduce the examples themselves and gain a deeper understanding of the many practical benefits of pharmacometrics.

Clinical pharmacologists/pharmacokineticists and pharmacometricians in drug development and pharmacotherapy, as well as students in clinical pharmacy, pharmaceutical sciences, and clinical pharmacology, should take advantage of this text to gain the training and knowledge needed to excel in pharmacometrics. More experienced pharmacometricians will want to keep the text on hand to address questions and further develop their skills.

About the Author
ENE I. ETTE, PhD, is a Fellow of the American Colleges of Clinical Pharmacy and Clinical Pharmacology. He is the President/CEO of Anoixis Corp. and was formerly the senior director and head of clinical pharmacology at Vertex Pharmaceuticals, Inc. He is also an adjunct professor of applied pharmaceutical sciences at the University of Rhode Island. Dr. Ette was a pioneer pharmacometric staff in the Office of Clinical Pharmacology and Biopharmaceutics at the Food and Drug Administration, where he developed the popular reference Guidance for Industry: Population Pharmacokinetics. From 1989 –2001, he was an FDA Consultant. In recognition of his contributions to clinical pharmacy and clinical pharmacology, Dr. Ette is the recipient of The American College of Clinical Pharmacy's Russell Miller Award. He is also the 2006 recipient of The American College of Clinical Pharmacy's Therapeutic Frontiers Lecture Award. Dr. Ette is chairman of the pharmacometrics panel of The Annals of Pharmacotherapy editorial board.

PAUL J. WILLIAMS, PharmD, is a Fellow of the American Colleges of Clinical Pharmacy and Clinical Pharmacology and Professor of Pharmaceutical Sciences and Pharmacy Practice at the Thomas J. Long School of Pharmacy and Health Sciences. Dr. Williams is the Vice President, Strategic Consulting, West Coast Operations in Anoixis Corp. and was formerly a partner at Trials by Design, LLC, a clinical consulting company, and member of the editorial board for The Annals of Pharmacotherapy. Dr. Williams is the 2006 winner of the University of the Pacific Faculty Research Award, the Long's Faculty Fellowship, and Teacher of the Year.

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